Today, Wednesday, September 2, 2026, the practical component of the specialized training course in Immunohistochemistry (IHC) was continued at the Center, focusing on the microscopic examination and interpretation of immunohistochemical results.

The practical session focused on stained tissue sections obtained from colorectal cancer specimens, with particular emphasis on evaluating the presence of immunoreactive signals, their cellular and tissue localization, the percentage of positive cells, staining intensity, and the distribution pattern of the immunoreactivity.

The training also included the assessment of staining quality and the differentiation of specific immunoreactivity from nonspecific background staining.

Furthermore, the session addressed the interpretation of immunohistochemical expression patterns of protein biomarkers in conjunction with the morphological features of the tissue.

Particular attention was given to correlating the characteristics of the immunohistochemical signal with the proportion of reactive cells, their cellular localization, and spatial distribution, while taking into consideration the appropriate positive and negative controls before accepting and validating the results.

The significance of this stage lies in transforming microscopic observations into interpretable immunohistochemical findings that can be further analyzed and compared according to the nature of the biomarker and the scoring system or assessment criteria applied.

This practical approach supports the application of IHC in histopathological studies and cancer-related research, particularly in the evaluation of tissue biomarkers and their patterns of expression.

This practical training provides participants with a solid foundation in the analysis of immunohistochemical signals, their correlation with the histological context, and the interpretation of results according to appropriate scientific and research-based criteria.