{"id":2430,"date":"2026-02-16T18:12:25","date_gmt":"2026-02-16T16:12:25","guid":{"rendered":"https:\/\/lbtrc.edu.ly\/en\/?post_type=research-projects&#038;p=2430"},"modified":"2026-02-16T18:13:40","modified_gmt":"2026-02-16T16:13:40","slug":"prevalence-of-genetic-mutations-in-exon-10-of-the-cftr-gene-among-cystic-fibrosis-patients-in-libya","status":"publish","type":"research-projects","link":"https:\/\/lbtrc.edu.ly\/en\/research-projects\/prevalence-of-genetic-mutations-in-exon-10-of-the-cftr-gene-among-cystic-fibrosis-patients-in-libya\/","title":{"rendered":"Prevalence of Genetic Mutations in Exon 10 of the CFTR Gene Among Cystic Fibrosis Patients in Libya"},"content":{"rendered":"<p>Cystic fibrosis is an autosomal recessive genetic disease that is increasingly being identified in various populations, including Libya. It is caused by mutations in the CFTR gene located on chromosome 7, which encodes a protein essential for regulating salt and water balance in many organs. The most common mutation is \u0394F508, which leads to protein misfolding and results in severe clinical symptoms such as lung disease, pancreatic insufficiency, male infertility, and liver complications. Globally, over 2,000 mutations in the CFTR gene have been identified, but their distribution varies across populations. In Libya, there is a significant lack of molecular data on this disease, making genetic research an urgent priority.<\/p>\n<p>This study aims to investigate the prevalence of genetic mutations\u2014particularly the \u0394F508 mutation\u2014in exon 10 of the CFTR gene among patients with cystic fibrosis in Libya. The objectives include estimating the frequency of these mutations and examining their association with disease severity. The findings of this study may contribute to improved genetic counseling, more accurate diagnosis, and better access to modern therapies, such as CFTR modulator treatments, in Libya.<\/p>\n","protected":false},"parent":0,"template":"","scientific-departments":[14],"class_list":["post-2430","research-projects","type-research-projects","status-publish","has-post-thumbnail","hentry","scientific-departments-genetic-engineering-department"],"acf":[],"_links":{"self":[{"href":"https:\/\/lbtrc.edu.ly\/en\/wp-json\/wp\/v2\/research-projects\/2430","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lbtrc.edu.ly\/en\/wp-json\/wp\/v2\/research-projects"}],"about":[{"href":"https:\/\/lbtrc.edu.ly\/en\/wp-json\/wp\/v2\/types\/research-projects"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lbtrc.edu.ly\/en\/wp-json\/wp\/v2\/media\/1493"}],"wp:attachment":[{"href":"https:\/\/lbtrc.edu.ly\/en\/wp-json\/wp\/v2\/media?parent=2430"}],"wp:term":[{"taxonomy":"scientific-departments","embeddable":true,"href":"https:\/\/lbtrc.edu.ly\/en\/wp-json\/wp\/v2\/scientific-departments?post=2430"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}